Abstract: Objective To analyze the expression of FKBP12 and FKBP52 in hepatocellular carcinoma（HCC） and explore its rela-tionship with clinicopathological factors. Methods Expression of FKBP12 and FKBP52 was measured in 60 samples of HCC tissue， 60 samples of normal adjacent tissue，10 samples of hepatic hemangioma and 10 cases of normal liver tissue.Expression was analyzed using the immunohistochemical streptavidin-peroxidase method and correlated with clinicopathological factors. Results Expression of FKBP12 was detected in 66.7% of HCC samples，a rate significantly higher than the 30.0% of adjacent tissues，20.0% of liver hemangioma and 40.0% of normal liver tissues（P<0.05）.The rate of FKBP52 expression was significantly higher in HCC tissues （63.3%） than in adjacent tissues （26.7%） and normal liver tissues （20.0%），but similar to the rate in liver hemangioma （40.0%）.Rates of FKBP12 and FKBP52 expression were similar in HCC tissues.There was no significant relationship between FKBP12 expression in HCC tissue and patient age，gender，cirrhosis， or hepatitis B virus infection，but expression was related to tumor size，pathology grade，and serum AFP level.There was no significant relationship between FKBP52 expression in HCC tissue and age，gender， tumor size，cirrhosis， or serum AFP level（P>0.05），but expression was related to pathology grade and hepatitis B virus infection（P<0.05）. Conclusion Expression of FKBP12 and FKBP52 correlate closely with incidence of HCC.FKBP12 may be involved in the proliferation and differentiation of tumor cells，and it may contribute to elevated serum AFP levels in liver cancer patients.FKBP52 may contribute to the differentiation of hepatocellular carcinoma and may participate in cellular processes in liver infected by hepatitis B virus.

Key words: Liver neoplasm, Hepatocellular carcinoma, FKBP12；FKBP52, Immunohistochemistry